The Tampa Bay Buccaneers head to Buffalo on Sunday with a chance to prove they’re still a serious NFC threat, even while limping into one of the league’s toughest road environments. Both teams sit at 6-3, but the Bills are 5 1/2-point favorites at home, boasting the NFL’s No. 2 offense and top-ranked rushing attack. Tampa Bay, however, brings a plus-8 turnover differential, a surging quarterback, and a defense that loves to blitz.

Injuries will force the Bucs to lean on their depth.

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Mike Evans (clavicle), Chris Godwin (fibula), Jalen McMillan (neck) and RB Bucky Irving (foot, shoulder) are all out, and edge rusher Haason Reddick isn’t expected to play. Still, Baker Mayfield has been efficient, throwing 16 touchdowns against just two interceptions.

Rookie receiver Emeka Egbuka has emerged as his go-to target, already posting three 100-yard games and 677 yards on 40 catches, putting him in rare company historically for a first-year wideout.

Tampa Bay’s offense will likely flow through Mayfield, Egbuka, tight end Cade Otton and emerging rookie Tez Johnson, with Sean Tucker trying to build on his 53 rushing yards last week against a stout Patriots front. The Bucs’ passing attack ranks 14th, and they’re 11th in scoring despite struggles on the ground.

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Defensively, the game may hinge on how well Tampa Bay contains Josh Allen and RB James Cook. Buffalo is 5-0 this year when Cook tops 100 rushing yards, but the Bucs’ run defense sits 11th and is anchored by Vita Vea, fresh off matching a career high with seven pressures. Tampa Bay also brings the league’s sixth-highest blitz rate, a potential problem for Allen, who’s already been sacked 20 times and has seven giveaways in his last six starts.

It’s a tough assignment, but if the Bucs can win the turnover battle and make Buffalo one-dimensional, an upset in Orchard Park is firmly on the table.