The Premier League club were victorious 2-0 last week, with Mason Mount and Ben Chilwell scoring the goals in Seville.
The Spanish city will also play host to this evening’s fixture, in which Porto will certainly be underdogs as they try to reach the next round and a semi-final against Real Madrid or Liverpool – with the La Liga champions having recorded a 3-1 win in the first leg of those teams’ last-eight tie.
Chelsea defeated Crystal Palace 4-1 in the Premier League at the weekend and will carry momentum from that victory into this match against the Portuguese champions, who beat Tondela 2-0 in their most recent outing.
Here’s everything you need to know about tonight’s game.
When is it?
The match will kick off at 8pm GMT this evening.
How can I watch it?
The fixture will air live on BT Sport 2. Subscribers can also stream the action live on the broadcaster’s website and app.
What is the team news?
Following a successful first leg and considering their upcoming FA Cup semi-final against Manchester City, Chelsea’s fully fit squad could see some rotations here.
Porto, meanwhile, will be glad to have Taremi and Sergio Oliveira – who has bagged 19 goals so far this season – back from suspension.
Chelsea: Mendy; Azpilicueta, Silva, Christensen; James, Kovacic, Kante, Alonso; Ziyech, Mount; Giroud
Porto:Marchesin; Manafa, Mbemba, Pepe, Sanusi; Corona, Uribe, Oliveira, Otavio; Marega, Taremi
Chelsea must beware a stunning Champions League comeback, a few of which we’ve seen in recent seasons, but they should have the quality – and composure under Tuchel – to get over the line here. Chelsea 1-0 Porto.