The Toffees and the Lilywhites have both had up and down campaigns as they struggle to find a sustained run of form that indicates they are moving in the right direction.
Both sides can close the gap to within a handful of points to fourth place West Ham with a victory, so it’s still all to play for heading into the clash at Goodison Park.
Here is all you need to know ahead of the match.
When is it?
The match will kick off at 8pm GMT on Friday, April 16.
How can I watch it?
The fixture will air live on Sky Sports Main Event and Sky Sports Premier League. Subscribers will also be able to watch the match online.
What is the team news?
Everton prepare to welcome back a crucial quartet of players with Jordan Pickford, Allan, Andre Gomes and Dominic Calvert-Lewin all hoping to return for Ancelotti’s side.
But Yerry Mina is unavailable for the coming weeks as he joins the list of absentees which also includes Bernard, Jean-Philippe Gbamin, Fabian Delph and Abdoulaye Doucoure.
Meanwhile, Spurs remain without Ben Davies and Matt Doherty but have no fresh injury concerns.
Everton: Pickford; Coleman, Holgate, Godfrey, Keane, Digne; Allan, Sigurdsson, Rodriguez; Calvert-Lewin, Richarlison
Tottenham: Lloris; Aurier, Alderweireld, Dier, Reguilon; Hojbjerg, Sissoko; Lucas, Ndombele, Son; Kane
Everton – 23/10
Tottenham – 23/20
Everton seem to bounce between the sublime to the ridiculous so you’re never quite sure what you’re going to get from them. By contrast, you’re almost certain at this point what you’re going to get from Mourinho’s Spurs side. If the visitors allow the Toffees to come onto them like they almost certainly will, Everton should eventually make them pay.2-1 Everton.