The match is set to be a thriller with hosts Dortmund having to throw everything they have at the match as they head into it 2-1 down after losing the first leg.
Edin Terzic’s team will also want to avenge the loss as they equalised in the 84th minute of the first leg only for Phil Foden to score the winner in the 90th.
While there will be no fans present to watch the match, Dortmund will still have the home advantage. Though City are favourites heading into the clash, the German club will fight to the end to progress in the Champions League.
Here’s all you need to know ahead of the fixture.
When is it?
The match will kick off at 8pm GMT on Wednesday, April 14.
How can I watch it?
The fixture will air live on BT Sport 3. Subscribers can also stream the action live on the broadcaster’s website and app.
What is the team news?
While Jadon Sancho has returned to training, he will not feature in the match and despite having injury scares at the weekend both Marcos Reus and Mats Hummels should be fit for the fixture.
Meanwhile for City, after they were rested at the weekend stars Ruben Dias, Rodri, Ilkay Gundogan, Phil Foden, Riyad Mahrez and Kevin De Bruyne are all expected to star for the visitors.
Dortmund: Hitz; Meunier, Akanji, Hummels, Guerreiro; Can, Bellingham, Dahoud; Knauff, Haaland, Reus
Man City: Ederson; Walker, Dias, Stones, Cancelo; Rodri, Gundogan, De Bruyne; Mahrez, Silva, Foden
Man City: 15/8
City could have more firepower with their rested players raring to go and they will want to get their side back to winning ways after they fell to defeat against Leeds United at the weekend. Despite Dortmund having star quality in Haaland, it won’t be enough to overcome the lead City already have. Dortmund 1-3 Manchester City (agg 2-5).